Regional Atrophy Analysis of MRI for Early Detection of Alzheimer's Disease

Regional Atrophy analysis of structural magnetic resonance image (MRI) of the brain may provide quantitative evidence of different neurodegenerative diseases. This paper proposes an approach for early detection of Alzheimer disease (AD) by locating the atrophy in the brain. The paper proposes an automated computer aided system to for differential diagnosis of different neurodegenerative diseases by regional atrophy analysis such as the hippocampus that is well known to be affected in early Alzheimer disease (AD). The paper proposes in calculated factors to be used in differential diagnosis of different neurodegenerative diseases. The proposed system with its modules; preprocessing, segmentation, regional analysis, detection and evaluation yielded promising results.